OCCURRENCE OF HIGH MICROSATELLITE-INSTABILITY/MISMATCH REPAIR DEFICIENCY IN NEARLY 2,000 HUMAN ADENOCARCINOMAS OF THE GASTROINTESTINAL TRACT, PANCREAS, AND BILE DUCTS: A STUDY FROM A LARGE GERMAN COMPREHENSIVE CANCER CENTER

IntroductionKnowledge of the high microsatellite-instability (MSI-H)/mismatch repair deficiency (MMRd) status is of increasing interest for personalized neoadjuvant or adjuvant therapy planning.Only a few studies are available on MSI-H distribution in the Neuro-Max Northern European Caucasian patient population.In this study, we focused on a large

Abstract Background The SARS-CoV-2 pandemic is currently leading to increasing numbers of COVID-19 patients all over the world.Clinical presentations range from asymptomatic, mild respiratory tract infection, to severe cases with acute respiratory distress syndrome, respiratory failure, and death.Reports on a dysregulated immune system in the sever

Introduction: Breast cancer is one of the most common malignancies, with few subtypes having a more aggressive outcome and resistance to conventional therapies, Triple Negative Breast Cancers (TNBCs) being one such variant.The Ki-67 lacks reproducibility and a standardised cut-off.MCM2 (Minichromosome Maintenance 2) has role in DNA repair and repli

The DMPTool NIH Data Management and Sharing Plan (DMSP) Templates Project was launched in response to the 2023 NIH Data Management and Sharing (DMS) Policy.This new policy introduced a more PRO B12 structured framework for DMS Plans, featuring six key elements, a departure from the 2003 NIH DMS policy.The project aimed to simplify the process for d

PCR-RFLP technique has been used to detect species-specific mutations of organelles DNA for closely related dwarf mountain pine (Pinus mugo) and Scots pine (P.sylvestris).Restriction fragment patterns have been compared of amplification products for trnL-trnF cpDNA and for coxI and orf25 genes Gaming Desk of mtDNA.The difference has been found in t